Drug interactions
Fluoxetine + Pasireotide
Severity: Moderate
Fluoxetine and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Pasireotide also causes bradycardia and may alter glucose and electrolyte balance, which raises the risk of torsades de pointes when it is combined with fluoxetine.
What this interaction means in plain words
Fluoxetine and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Pasireotide belongs to Endocrine.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization, with pasireotide-related bradycardia as an added risk factor.
What to do
Obtain a baseline ECG and repeat it after starting or changing doses. Correct hypokalemia and hypomagnesemia, and monitor electrolytes during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluoxetine and Pasireotide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Fluoxetine with Pasireotide?
MediHelp rates the interaction as moderate. Fluoxetine and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval. Pasireotide also causes bradycardia and may alter glucose and electrolyte balance, which raises the risk of torsades de pointes when it is combined with fluoxetine.
How serious is the interaction between Fluoxetine and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it after starting or changing doses. Correct hypokalemia and hypomagnesemia, and monitor electrolytes during treatment.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
