Drug interactions
Fluoxetine + Selpercatinib
Severity: Moderate
Fluoxetine and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval and fluoxetine has some QT-prolonging potential, so combined use may increase arrhythmia risk. Risk is higher with electrolyte disturbances or heart disease.
What this interaction means in plain words
Fluoxetine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Selpercatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG and electrolytes at baseline and periodically during therapy, correcting any abnormalities. Reduce or interrupt selpercatinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Fluoxetine with Selpercatinib?
MediHelp rates the interaction as moderate. Fluoxetine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval and fluoxetine has some QT-prolonging potential, so combined use may increase arrhythmia risk. Risk is higher with electrolyte disturbances or heart disease.
How serious is the interaction between Fluoxetine and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically during therapy, correcting any abnormalities. Reduce or interrupt selpercatinib if QTc becomes markedly prolonged.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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