Drug interactions
Fluoxetine + Sorafenib
Severity: Moderate
Fluoxetine and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are associated with QT prolongation, so combined use may increase the risk of ventricular arrhythmia. Risk is higher with electrolyte abnormalities or cardiac disease.
What this interaction means in plain words
Fluoxetine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and electrolytes, correcting potassium and magnesium abnormalities. Consider an alternative antidepressant with less QT effect in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Fluoxetine with Sorafenib?
MediHelp rates the interaction as moderate. Fluoxetine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are associated with QT prolongation, so combined use may increase the risk of ventricular arrhythmia. Risk is higher with electrolyte abnormalities or cardiac disease.
How serious is the interaction between Fluoxetine and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, correcting potassium and magnesium abnormalities. Consider an alternative antidepressant with less QT effect in high-risk patients.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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