Drug interactions
Fluoxetine + Timolol
Severity: Moderate
Fluoxetine and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine inhibits CYP2D6, which is the main route of timolol metabolism, and can raise timolol concentrations. This may cause bradycardia and hypotension, and has been reported even with timolol eye drops.
What this interaction means in plain words
Fluoxetine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated timolol metabolism increases systemic exposure.
What to do
Monitor heart rate and blood pressure when starting or stopping fluoxetine, and lower the timolol dose if bradycardia occurs. Consider an alternative glaucoma agent if effects persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Timolol?
MediHelp rates the interaction as moderate. Fluoxetine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine inhibits CYP2D6, which is the main route of timolol metabolism, and can raise timolol concentrations. This may cause bradycardia and hypotension, and has been reported even with timolol eye drops.
How serious is the interaction between Fluoxetine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping fluoxetine, and lower the timolol dose if bradycardia occurs. Consider an alternative glaucoma agent if effects persist.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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