Drug interactions
Fluoxetine + Tolmetin
Severity: Moderate
Fluoxetine and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine with an NSAID increases the risk of upper gastrointestinal bleeding. Risk is highest in older adults and those with prior ulcers.
What this interaction means in plain words
Fluoxetine and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Tolmetin belongs to Musculoskeletal.
Why it happens
SSRI depletion of platelet serotonin impairs aggregation, adding to NSAID COX-1 inhibition and mucosal damage.
What to do
Use the lowest effective NSAID dose for the shortest time and consider a proton pump inhibitor. Monitor for GI bleeding and anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Tolmetin?
MediHelp rates the interaction as moderate. Fluoxetine and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine with an NSAID increases the risk of upper gastrointestinal bleeding. Risk is highest in older adults and those with prior ulcers.
How serious is the interaction between Fluoxetine and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and consider a proton pump inhibitor. Monitor for GI bleeding and anemia.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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