Drug interactions
Fluoxetine + Zuranolone
Severity: Moderate
Fluoxetine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes sedation and impaired psychomotor performance, and other CNS-active drugs such as fluoxetine can add to these effects. Patients may have more somnolence, dizziness and trouble driving. Fluoxetine is often given alongside zuranolone in practice, so the combination is manageable in many patients.
What this interaction means in plain words
Fluoxetine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through pharmacodynamic synergism.
What to do
Counsel patients not to drive or do hazardous tasks for at least 12 hours after each zuranolone dose. Reduce the zuranolone dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Fluoxetine with Zuranolone?
MediHelp rates the interaction as moderate. Fluoxetine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes sedation and impaired psychomotor performance, and other CNS-active drugs such as fluoxetine can add to these effects. Patients may have more somnolence, dizziness and trouble driving. Fluoxetine is often given alongside zuranolone in practice, so the combination is manageable in many patients.
How serious is the interaction between Fluoxetine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients not to drive or do hazardous tasks for at least 12 hours after each zuranolone dose. Reduce the zuranolone dose if excessive sedation occurs.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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