Drug interactions
Fluoxymesterone + Tacrolimus
Severity: Moderate
Fluoxymesterone and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens may increase tacrolimus levels, which can raise the risk of nephrotoxicity. Evidence is limited to the effect of related steroid hormones and isolated reports.
What this interaction means in plain words
Fluoxymesterone and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of CYP3A4-mediated tacrolimus metabolism; the mechanism is not firmly established.
What to do
Monitor tacrolimus trough levels and renal function when starting or stopping fluoxymesterone, and adjust the tacrolimus dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Fluoxymesterone with Tacrolimus?
MediHelp rates the interaction as moderate. Fluoxymesterone and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgens may increase tacrolimus levels, which can raise the risk of nephrotoxicity. Evidence is limited to the effect of related steroid hormones and isolated reports.
How serious is the interaction between Fluoxymesterone and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function when starting or stopping fluoxymesterone, and adjust the tacrolimus dose accordingly.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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