Drug interactions
Fluphenazine + Flurazepam
Severity: Moderate
Fluphenazine and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam and fluphenazine both cause CNS depression, so together they may increase drowsiness, dizziness and psychomotor impairment. Flurazepam has long-acting active metabolites, so the effect can persist, especially in older adults.
What this interaction means in plain words
Fluphenazine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A enhancement and phenothiazine receptor blockade.
What to do
Use the lowest effective doses, monitor for daytime sedation and falls, and consider a shorter-acting alternative in older patients. Advise avoiding alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Flurazepam?
MediHelp rates the interaction as moderate. Fluphenazine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam and fluphenazine both cause CNS depression, so together they may increase drowsiness, dizziness and psychomotor impairment. Flurazepam has long-acting active metabolites, so the effect can persist, especially in older adults.
How serious is the interaction between Fluphenazine and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, monitor for daytime sedation and falls, and consider a shorter-acting alternative in older patients. Advise avoiding alcohol and driving.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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