Drug interactions
Fluphenazine + Formoterol
Severity: Moderate
Fluphenazine and Formoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both formoterol and fluphenazine can prolong the QTc interval. Combining them may raise the chance of torsades de pointes, especially in patients with hypokalemia, bradycardia or structural heart disease.
What this interaction means in plain words
Fluphenazine and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Formoterol belongs to Respiratory.
Why it happens
Additive QT prolongation through pharmacodynamic effects on cardiac repolarization, with possible beta-agonist related hypokalemia.
What to do
Monitor ECG and serum potassium when starting or adjusting either drug, and keep formoterol at the lowest effective dose. Consider an alternative if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Formoterol?
MediHelp rates the interaction as moderate. Fluphenazine and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both formoterol and fluphenazine can prolong the QTc interval. Combining them may raise the chance of torsades de pointes, especially in patients with hypokalemia, bradycardia or structural heart disease.
How serious is the interaction between Fluphenazine and Formoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium when starting or adjusting either drug, and keep formoterol at the lowest effective dose. Consider an alternative if QTc becomes prolonged.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
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