Drug interactions
Fluphenazine + Hyoscyamine spray
Severity: Moderate
Fluphenazine and Hyoscyamine spray: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral hyoscyamine spray is absorbed through the mouth and adds to the anticholinergic effects of fluphenazine. This may result in dry mouth, constipation, urinary retention, tachycardia and confusion.
What this interaction means in plain words
Fluphenazine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic adverse effects and use the lowest effective hyoscyamine dose. Take extra care in older patients and those with urinary retention or glaucoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Hyoscyamine spray?
MediHelp rates the interaction as moderate. Fluphenazine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral hyoscyamine spray is absorbed through the mouth and adds to the anticholinergic effects of fluphenazine. This may result in dry mouth, constipation, urinary retention, tachycardia and confusion.
How serious is the interaction between Fluphenazine and Hyoscyamine spray?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and use the lowest effective hyoscyamine dose. Take extra care in older patients and those with urinary retention or glaucoma.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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