Drug interactions
Fluphenazine + Levorphanol
Severity: Major
Fluphenazine and Levorphanol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and phenothiazines both depress the central nervous system. Together they can cause profound sedation, hypotension and respiratory depression.
What this interaction means in plain words
Fluphenazine and Levorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system and respiratory depression.
What to do
Start with reduced doses of levorphanol and titrate carefully. Monitor sedation level and respiratory rate, and avoid other CNS depressants such as alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Levorphanol?
MediHelp rates the interaction as major. Fluphenazine and Levorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids and phenothiazines both depress the central nervous system. Together they can cause profound sedation, hypotension and respiratory depression.
How serious is the interaction between Fluphenazine and Levorphanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced doses of levorphanol and titrate carefully. Monitor sedation level and respiratory rate, and avoid other CNS depressants such as alcohol.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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