Drug interactions
Fluphenazine + Lormetazepam
Severity: Moderate
Fluphenazine and Lormetazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating and their combined use can cause increased drowsiness, slowed reaction time and impaired coordination. Older patients are at higher risk of falls and confusion.
What this interaction means in plain words
Fluphenazine and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression through GABA-A potentiation and phenothiazine sedative effects.
What to do
Use the lowest effective doses and caution about driving and alcohol. Monitor for oversedation, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Lormetazepam?
MediHelp rates the interaction as moderate. Fluphenazine and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating and their combined use can cause increased drowsiness, slowed reaction time and impaired coordination. Older patients are at higher risk of falls and confusion.
How serious is the interaction between Fluphenazine and Lormetazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and caution about driving and alcohol. Monitor for oversedation, especially in older adults.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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