Drug interactions
Fluphenazine + Methylergonovine
Severity: Moderate
Fluphenazine and Methylergonovine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine is an ergot derivative with serotonergic activity and a vasoconstrictive effect, and antipsychotics may add to serotonergic effects. Serotonin toxicity or neuroleptic malignant syndrome are theoretical concerns, and the interaction is poorly documented.
What this interaction means in plain words
Fluphenazine and Methylergonovine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic activity and dopamine receptor modulation; the mechanism is not well established.
What to do
Monitor for signs of serotonin toxicity such as agitation, tremor, clonus and fever, and for muscle rigidity. Usually methylergonovine is given short term, so limit the duration of treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Methylergonovine?
MediHelp rates the interaction as moderate. Fluphenazine and Methylergonovine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylergonovine is an ergot derivative with serotonergic activity and a vasoconstrictive effect, and antipsychotics may add to serotonergic effects. Serotonin toxicity or neuroleptic malignant syndrome are theoretical concerns, and the interaction is poorly documented.
How serious is the interaction between Fluphenazine and Methylergonovine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as agitation, tremor, clonus and fever, and for muscle rigidity. Usually methylergonovine is given short term, so limit the duration of treatment.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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