Drug interactions
Fluphenazine + Metrizamide
Severity: Major
Fluphenazine and Metrizamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines lower the seizure threshold, and intrathecal metrizamide can itself provoke seizures. Combined use raises seizure risk during myelography.
What this interaction means in plain words
Fluphenazine and Metrizamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive lowering of seizure threshold; exact mechanism not fully established.
What to do
Stop fluphenazine at least 24 hours before the procedure and do not restart for at least 24 hours afterward. Use a non-ionic contrast agent where available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Metrizamide?
MediHelp rates the interaction as major. Fluphenazine and Metrizamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenothiazines lower the seizure threshold, and intrathecal metrizamide can itself provoke seizures. Combined use raises seizure risk during myelography.
How serious is the interaction between Fluphenazine and Metrizamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop fluphenazine at least 24 hours before the procedure and do not restart for at least 24 hours afterward. Use a non-ionic contrast agent where available.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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