Drug interactions
Fluphenazine + Mobocertinib
Severity: Major
Fluphenazine and Mobocertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib prolongs the QT interval and can cause torsades de pointes, and fluphenazine also has QT-prolonging potential. Using them together raises the risk of serious ventricular arrhythmia and sudden cardiac death.
What this interaction means in plain words
Fluphenazine and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive prolongation of cardiac repolarization through blockade of cardiac potassium channels (hERG).
What to do
Avoid the combination where an alternative antipsychotic is possible. If it cannot be avoided, reduce the mobocertinib dose per labeling, correct potassium and magnesium, and monitor ECG/QTc more often.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Mobocertinib?
MediHelp rates the interaction as major. Fluphenazine and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib prolongs the QT interval and can cause torsades de pointes, and fluphenazine also has QT-prolonging potential. Using them together raises the risk of serious ventricular arrhythmia and sudden cardiac death.
How serious is the interaction between Fluphenazine and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antipsychotic is possible. If it cannot be avoided, reduce the mobocertinib dose per labeling, correct potassium and magnesium, and monitor ECG/QTc more often.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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