Drug interactions
Fluphenazine + Parecoxib
Severity: Minor
Fluphenazine and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib's active metabolite valdecoxib is a weak CYP2D6 inhibitor in vitro, which could marginally raise fluphenazine concentrations. A clinically meaningful effect is unlikely.
What this interaction means in plain words
Fluphenazine and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP2D6 inhibition reducing fluphenazine metabolism.
What to do
No routine action is needed; monitor for increased sedation or extrapyramidal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Parecoxib?
MediHelp rates the interaction as minor. Fluphenazine and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib's active metabolite valdecoxib is a weak CYP2D6 inhibitor in vitro, which could marginally raise fluphenazine concentrations. A clinically meaningful effect is unlikely.
How serious is the interaction between Fluphenazine and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor for increased sedation or extrapyramidal symptoms.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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