Drug interactions
Fluphenazine + Scullcap
Severity: Minor
Fluphenazine and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap herbal products have traditionally been used for sedation and anxiety and may add to the drowsiness caused by fluphenazine. Evidence is limited and products vary in quality, with some reports of liver toxicity from adulterated preparations.
What this interaction means in plain words
Fluphenazine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression, likely through GABAergic activity of skullcap constituents.
What to do
Advise patients to avoid skullcap or monitor for excess sedation, and to disclose herbal use. Report jaundice or other signs of liver injury.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Scullcap?
MediHelp rates the interaction as minor. Fluphenazine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap herbal products have traditionally been used for sedation and anxiety and may add to the drowsiness caused by fluphenazine. Evidence is limited and products vary in quality, with some reports of liver toxicity from adulterated preparations.
How serious is the interaction between Fluphenazine and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid skullcap or monitor for excess sedation, and to disclose herbal use. Report jaundice or other signs of liver injury.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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