Drug interactions
Fluphenazine + Yohimbine
Severity: Moderate
Fluphenazine and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that raises sympathetic activity and may cause anxiety, tachycardia and hypertension, partly opposing the sedation of fluphenazine. Phenothiazine alpha-blockade may be counteracted, and effects on blood pressure and heart rhythm are unpredictable.
What this interaction means in plain words
Fluphenazine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing adrenergic effects: alpha-2 antagonism by yohimbine versus alpha-1 blockade and sedation by fluphenazine; mechanism not firmly established.
What to do
Monitor blood pressure, heart rate and psychiatric symptoms such as anxiety or agitation. Avoid in patients with cardiovascular disease or psychosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Yohimbine?
MediHelp rates the interaction as moderate. Fluphenazine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that raises sympathetic activity and may cause anxiety, tachycardia and hypertension, partly opposing the sedation of fluphenazine. Phenothiazine alpha-blockade may be counteracted, and effects on blood pressure and heart rhythm are unpredictable.
How serious is the interaction between Fluphenazine and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and psychiatric symptoms such as anxiety or agitation. Avoid in patients with cardiovascular disease or psychosis.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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