Drug interactions
Flurazepam + Haloperidol
Severity: Moderate
Flurazepam and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting benzodiazepine hypnotic and haloperidol also causes sedation. Combined use increases drowsiness, impaired coordination and cognitive slowing, with a greater risk of falls and confusion in older adults.
What this interaction means in plain words
Flurazepam and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation by flurazepam and central dopamine and histamine blockade by haloperidol.
What to do
Use the lowest effective dose of each drug and monitor for oversedation and falls, particularly in elderly patients. Consider a shorter-acting hypnotic if combined therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Flurazepam with Haloperidol?
MediHelp rates the interaction as moderate. Flurazepam and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting benzodiazepine hypnotic and haloperidol also causes sedation. Combined use increases drowsiness, impaired coordination and cognitive slowing, with a greater risk of falls and confusion in older adults.
How serious is the interaction between Flurazepam and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of each drug and monitor for oversedation and falls, particularly in elderly patients. Consider a shorter-acting hypnotic if combined therapy is needed.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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