Drug interactions
Flurazepam + Hydroxyzine
Severity: Moderate
Flurazepam and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can produce deeper sedation, drowsiness and impaired psychomotor performance. Older adults and patients with respiratory disease are at higher risk of falls and next-day impairment.
What this interaction means in plain words
Flurazepam and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from H1-receptor antagonism by hydroxyzine and GABA-A potentiation by flurazepam.
What to do
Use the lowest effective doses and avoid combining in elderly patients where possible. Counsel patients about driving and alcohol and monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Flurazepam with Hydroxyzine?
MediHelp rates the interaction as moderate. Flurazepam and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can produce deeper sedation, drowsiness and impaired psychomotor performance. Older adults and patients with respiratory disease are at higher risk of falls and next-day impairment.
How serious is the interaction between Flurazepam and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid combining in elderly patients where possible. Counsel patients about driving and alcohol and monitor for excessive sedation.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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