Drug interactions
Flurazepam + Itraconazole
Severity: Moderate
Flurazepam and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may raise levels of flurazepam and its active metabolites, intensifying and prolonging sedation. Impaired psychomotor function, falls and respiratory depression are more likely, especially in older patients.
What this interaction means in plain words
Flurazepam and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition reduces metabolism of flurazepam.
What to do
Use a reduced flurazepam dose and monitor for oversedation. Consider a benzodiazepine that is not CYP3A4-dependent, such as temazepam or lorazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Flurazepam with Itraconazole?
MediHelp rates the interaction as moderate. Flurazepam and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may raise levels of flurazepam and its active metabolites, intensifying and prolonging sedation. Impaired psychomotor function, falls and respiratory depression are more likely, especially in older patients.
How serious is the interaction between Flurazepam and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced flurazepam dose and monitor for oversedation. Consider a benzodiazepine that is not CYP3A4-dependent, such as temazepam or lorazepam.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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