Drug interactions
Flurazepam + Nabilone
Severity: Moderate
Flurazepam and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting benzodiazepine whose active metabolite accumulates, and nabilone adds sedation and psychomotor impairment. Daytime drowsiness, confusion and falls are more likely.
What this interaction means in plain words
Flurazepam and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation and cannabinoid receptor agonism.
What to do
Use the lowest effective doses, avoid in older adults where possible, and monitor for next-day sedation. Warn against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Frequently asked questions
Can I take Flurazepam with Nabilone?
MediHelp rates the interaction as moderate. Flurazepam and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting benzodiazepine whose active metabolite accumulates, and nabilone adds sedation and psychomotor impairment. Daytime drowsiness, confusion and falls are more likely.
How serious is the interaction between Flurazepam and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, avoid in older adults where possible, and monitor for next-day sedation. Warn against driving and alcohol.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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