Drug interactions
Flurazepam + Perphenazine
Severity: Moderate
Flurazepam and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting benzodiazepine, and with perphenazine it can cause additive sedation, impaired coordination and next-day drowsiness. Falls and respiratory depression are concerns, particularly in older adults.
What this interaction means in plain words
Flurazepam and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and antipsychotic sedation.
What to do
Use the lowest effective flurazepam dose and monitor for daytime sedation and falls. Consider a shorter-acting hypnotic in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Flurazepam with Perphenazine?
MediHelp rates the interaction as moderate. Flurazepam and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting benzodiazepine, and with perphenazine it can cause additive sedation, impaired coordination and next-day drowsiness. Falls and respiratory depression are concerns, particularly in older adults.
How serious is the interaction between Flurazepam and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective flurazepam dose and monitor for daytime sedation and falls. Consider a shorter-acting hypnotic in older patients.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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