Drug interactions
Flurazepam + Ribociclib
Severity: Moderate
Flurazepam and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam and its active metabolite are cleared in part by CYP3A4. Ribociclib may increase exposure, causing prolonged sedation, confusion and falls, especially in older adults.
What this interaction means in plain words
Flurazepam and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4, reducing flurazepam metabolism.
What to do
Monitor for oversedation and consider reducing the flurazepam dose or using a benzodiazepine not dependent on CYP3A4, such as lorazepam or temazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Flurazepam with Ribociclib?
MediHelp rates the interaction as moderate. Flurazepam and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam and its active metabolite are cleared in part by CYP3A4. Ribociclib may increase exposure, causing prolonged sedation, confusion and falls, especially in older adults.
How serious is the interaction between Flurazepam and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider reducing the flurazepam dose or using a benzodiazepine not dependent on CYP3A4, such as lorazepam or temazepam.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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