Drug interactions
Flurazepam + Voriconazole
Severity: Moderate
Flurazepam and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can increase flurazepam and its active metabolite concentrations, intensifying sedation and psychomotor impairment. Respiratory depression is possible, particularly in older patients.
What this interaction means in plain words
Flurazepam and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of flurazepam and its active metabolite.
What to do
Consider reducing the flurazepam dose or using a benzodiazepine not dependent on CYP3A4 such as lorazepam, and monitor sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Flurazepam with Voriconazole?
MediHelp rates the interaction as moderate. Flurazepam and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can increase flurazepam and its active metabolite concentrations, intensifying sedation and psychomotor impairment. Respiratory depression is possible, particularly in older patients.
How serious is the interaction between Flurazepam and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the flurazepam dose or using a benzodiazepine not dependent on CYP3A4 such as lorazepam, and monitor sedation.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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