Drug interactions
Flurbiprofen + Fosinopril-hydrochlorothiazide
Severity: Moderate
Flurbiprofen and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen can reduce the antihypertensive efficacy of fosinopril and hydrochlorothiazide. The combination may impair renal function, particularly with dehydration, advanced age or existing kidney disease.
What this interaction means in plain words
Flurbiprofen and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
NSAID-mediated inhibition of vasodilatory renal prostaglandins reduces glomerular filtration and sodium excretion, counteracting both antihypertensives.
What to do
Use paracetamol or another alternative when possible. If co-administered, give the lowest effective flurbiprofen dose briefly and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Flurbiprofen and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen can reduce the antihypertensive efficacy of fosinopril and hydrochlorothiazide. The combination may impair renal function, particularly with dehydration, advanced age or existing kidney disease.
How serious is the interaction between Flurbiprofen and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use paracetamol or another alternative when possible. If co-administered, give the lowest effective flurbiprofen dose briefly and monitor blood pressure, creatinine and potassium.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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