Drug interactions
Flurbiprofen + Glimepiride
Severity: Moderate
Flurbiprofen and Glimepiride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen is highly protein bound and metabolized by CYP2C9, as is glimepiride, so competition may modestly raise sulfonylurea exposure. NSAIDs may also enhance glucose-lowering, increasing the risk of hypoglycemia.
What this interaction means in plain words
Flurbiprofen and Glimepiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Glimepiride belongs to Endocrine.
Why it happens
Possible competition for CYP2C9 metabolism and protein binding, with NSAID effects on glucose homeostasis.
What to do
Monitor blood glucose more frequently when starting or stopping flurbiprofen and reduce the glimepiride dose if hypoglycemia occurs. Educate the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Flurbiprofen with Glimepiride?
MediHelp rates the interaction as moderate. Flurbiprofen and Glimepiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen is highly protein bound and metabolized by CYP2C9, as is glimepiride, so competition may modestly raise sulfonylurea exposure. NSAIDs may also enhance glucose-lowering, increasing the risk of hypoglycemia.
How serious is the interaction between Flurbiprofen and Glimepiride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or stopping flurbiprofen and reduce the glimepiride dose if hypoglycemia occurs. Educate the patient about hypoglycemia symptoms.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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