Drug interactions
Flurbiprofen + Imatinib
Severity: Moderate
Flurbiprofen and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and gastrointestinal bleeding, and flurbiprofen adds platelet inhibition and mucosal injury, raising bleeding risk. Imatinib also inhibits CYP2C9 to a modest degree and may raise flurbiprofen exposure.
What this interaction means in plain words
Flurbiprofen and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Imatinib belongs to Oncology.
Why it happens
Additive effects on hemostasis (thrombocytopenia plus platelet inhibition) and possible CYP2C9 inhibition by imatinib increasing flurbiprofen levels.
What to do
Monitor platelet counts and watch for bleeding or GI symptoms; prefer paracetamol for analgesia when possible. Use the lowest NSAID dose and consider gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Flurbiprofen with Imatinib?
MediHelp rates the interaction as moderate. Flurbiprofen and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and gastrointestinal bleeding, and flurbiprofen adds platelet inhibition and mucosal injury, raising bleeding risk. Imatinib also inhibits CYP2C9 to a modest degree and may raise flurbiprofen exposure.
How serious is the interaction between Flurbiprofen and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and watch for bleeding or GI symptoms; prefer paracetamol for analgesia when possible. Use the lowest NSAID dose and consider gastroprotection.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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