Drug interactions
Flurbiprofen + Irbesartan
Severity: Moderate
Flurbiprofen and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen can weaken the antihypertensive effect of irbesartan and, together, they increase the risk of acute kidney injury and hyperkalemia, particularly in older, dehydrated, or renally impaired patients.
What this interaction means in plain words
Flurbiprofen and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Irbesartan belongs to Cardiovascular.
Why it happens
NSAIDs reduce afferent arteriolar vasodilating prostaglandins while ARBs reduce efferent tone, decreasing glomerular filtration and potassium excretion.
What to do
Monitor blood pressure, serum creatinine and potassium within the first weeks of co-therapy and ensure hydration. Avoid prolonged use in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Flurbiprofen with Irbesartan?
MediHelp rates the interaction as moderate. Flurbiprofen and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen can weaken the antihypertensive effect of irbesartan and, together, they increase the risk of acute kidney injury and hyperkalemia, particularly in older, dehydrated, or renally impaired patients.
How serious is the interaction between Flurbiprofen and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium within the first weeks of co-therapy and ensure hydration. Avoid prolonged use in high-risk patients.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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