Drug interactions
Flurbiprofen + Levofloxacin
Severity: Moderate
Flurbiprofen and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones lower the seizure threshold and NSAIDs may add to this effect, particularly in patients with epilepsy, CNS disease or renal impairment. Seizures or CNS excitation are uncommon but can be serious.
What this interaction means in plain words
Flurbiprofen and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Levofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones antagonise GABA-A receptor activity and NSAIDs may potentiate this, producing additive CNS excitation.
What to do
Avoid the combination in patients with a seizure history or other predisposing factors, or choose a non-quinolone antibiotic. Otherwise monitor for tremor, agitation or seizure activity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flurbiprofen and Levofloxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Flurbiprofen with Levofloxacin?
MediHelp rates the interaction as moderate. Flurbiprofen and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones lower the seizure threshold and NSAIDs may add to this effect, particularly in patients with epilepsy, CNS disease or renal impairment. Seizures or CNS excitation are uncommon but can be serious.
How serious is the interaction between Flurbiprofen and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with a seizure history or other predisposing factors, or choose a non-quinolone antibiotic. Otherwise monitor for tremor, agitation or seizure activity.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
