Drug interactions
Flurbiprofen + Phentolamine
Severity: Minor
Flurbiprofen and Phentolamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may weaken the blood pressure lowering effect of antihypertensive agents. Evidence specific to phentolamine is limited and the effect is likely modest.
What this interaction means in plain words
Flurbiprofen and Phentolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flurbiprofen belongs to Musculoskeletal; Phentolamine belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium retention may oppose vasodilator effects; this is extrapolated from other antihypertensives.
What to do
Monitor blood pressure if an NSAID is used regularly alongside phentolamine and adjust the dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Flurbiprofen with Phentolamine?
MediHelp rates the interaction as minor. Flurbiprofen and Phentolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may weaken the blood pressure lowering effect of antihypertensive agents. Evidence specific to phentolamine is limited and the effect is likely modest.
How serious is the interaction between Flurbiprofen and Phentolamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if an NSAID is used regularly alongside phentolamine and adjust the dose if control worsens.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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