Drug interactions
Flurbiprofen + Pralatrexate
Severity: Moderate
Flurbiprofen and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce renal elimination of pralatrexate, raising exposure and the risk of mucositis, myelosuppression and other toxicity.
What this interaction means in plain words
Flurbiprofen and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
Why it happens
NSAIDs reduce renal blood flow and may compete for renal tubular secretion, delaying pralatrexate clearance.
What to do
Monitor for mucositis and blood count abnormalities and check renal function; consider avoiding the NSAID or adjusting the pralatrexate dose per labeling if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Pralatrexate
Frequently asked questions
Can I take Flurbiprofen with Pralatrexate?
MediHelp rates the interaction as moderate. Flurbiprofen and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce renal elimination of pralatrexate, raising exposure and the risk of mucositis, myelosuppression and other toxicity.
How serious is the interaction between Flurbiprofen and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mucositis and blood count abnormalities and check renal function; consider avoiding the NSAID or adjusting the pralatrexate dose per labeling if toxicity appears.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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