Drug interactions
Flurbiprofen + Prasugrel
Severity: Major
Flurbiprofen and Prasugrel: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prasugrel is a potent antiplatelet agent, and NSAIDs add platelet inhibition and gastrointestinal mucosal injury. Concurrent use raises the risk of clinically significant bleeding, especially gastrointestinal.
What this interaction means in plain words
Flurbiprofen and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flurbiprofen belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Additive antiplatelet effect (irreversible P2Y12 blockade plus reversible COX-1 inhibition) with NSAID-related mucosal damage.
What to do
Avoid regular NSAID use with prasugrel where possible and use paracetamol for analgesia; if unavoidable, consider gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Flurbiprofen with Prasugrel?
MediHelp rates the interaction as major. Flurbiprofen and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prasugrel is a potent antiplatelet agent, and NSAIDs add platelet inhibition and gastrointestinal mucosal injury. Concurrent use raises the risk of clinically significant bleeding, especially gastrointestinal.
How serious is the interaction between Flurbiprofen and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with prasugrel where possible and use paracetamol for analgesia; if unavoidable, consider gastroprotection and monitor for bleeding.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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