Drug interactions
Flurbiprofen + Prednisone
Severity: Moderate
Flurbiprofen and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using a corticosteroid together with an NSAID raises the likelihood of gastric ulcers and gastrointestinal bleeding. The risk is higher in older patients and with prolonged use.
What this interaction means in plain words
Flurbiprofen and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Prednisone belongs to Endocrine.
Why it happens
NSAIDs suppress mucosal prostaglandins while corticosteroids impair mucosal healing, producing additive gastrointestinal injury.
What to do
Use the lowest effective doses for the shortest duration and add gastroprotection with a proton pump inhibitor in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Prednisone?
MediHelp rates the interaction as moderate. Flurbiprofen and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using a corticosteroid together with an NSAID raises the likelihood of gastric ulcers and gastrointestinal bleeding. The risk is higher in older patients and with prolonged use.
How serious is the interaction between Flurbiprofen and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and add gastroprotection with a proton pump inhibitor in at-risk patients.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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