Drug interactions
Flurbiprofen + Probenecid
Severity: Moderate
Flurbiprofen and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces the renal clearance of flurbiprofen and other NSAIDs, increasing their plasma levels and the risk of NSAID adverse effects. Flurbiprofen may also blunt the uricosuric effect of probenecid.
What this interaction means in plain words
Flurbiprofen and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits organic anion transporters in the renal tubule and inhibits glucuronidation, decreasing NSAID elimination.
What to do
Consider a lower flurbiprofen dose and monitor for GI, renal and cardiovascular adverse effects. Watch for reduced urate-lowering effect in gout.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Flurbiprofen with Probenecid?
MediHelp rates the interaction as moderate. Flurbiprofen and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces the renal clearance of flurbiprofen and other NSAIDs, increasing their plasma levels and the risk of NSAID adverse effects. Flurbiprofen may also blunt the uricosuric effect of probenecid.
How serious is the interaction between Flurbiprofen and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower flurbiprofen dose and monitor for GI, renal and cardiovascular adverse effects. Watch for reduced urate-lowering effect in gout.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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