Drug interactions
Flurbiprofen + Rifapentine
Severity: Minor
Flurbiprofen and Rifapentine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP enzymes and may reduce flurbiprofen exposure. Reduced anti-inflammatory or analgesic effect is possible but probably small.
What this interaction means in plain words
Flurbiprofen and Rifapentine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flurbiprofen belongs to Musculoskeletal; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induction of hepatic CYP2C9 increases flurbiprofen metabolism.
What to do
Monitor pain control during rifapentine therapy and adjust the flurbiprofen dose or alternative if response is lacking.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Rifapentine?
MediHelp rates the interaction as minor. Flurbiprofen and Rifapentine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifapentine induces CYP enzymes and may reduce flurbiprofen exposure. Reduced anti-inflammatory or analgesic effect is possible but probably small.
How serious is the interaction between Flurbiprofen and Rifapentine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control during rifapentine therapy and adjust the flurbiprofen dose or alternative if response is lacking.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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