Drug interactions
Flurbiprofen + Sertraline
Severity: Moderate
Flurbiprofen and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with an NSAID markedly increases the risk of upper gastrointestinal bleeding versus either drug alone, particularly in older adults or those with prior ulcer disease.
What this interaction means in plain words
Flurbiprofen and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Sertraline belongs to Central Nervous System.
Why it happens
SSRIs reduce platelet serotonin and aggregation while NSAIDs inhibit platelet thromboxane and damage the gastric mucosa.
What to do
Consider a proton pump inhibitor in at-risk patients and counsel on signs of GI bleeding. Use the lowest effective NSAID dose or an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flurbiprofen and Sertraline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Sertraline?
MediHelp rates the interaction as moderate. Flurbiprofen and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SSRI with an NSAID markedly increases the risk of upper gastrointestinal bleeding versus either drug alone, particularly in older adults or those with prior ulcer disease.
How serious is the interaction between Flurbiprofen and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor in at-risk patients and counsel on signs of GI bleeding. Use the lowest effective NSAID dose or an alternative analgesic.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
