Drug interactions
Flurbiprofen + Tolfenamic acid
Severity: Major
Flurbiprofen and Tolfenamic acid: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two NSAIDs together increases the risk of gastrointestinal bleeding, renal injury and cardiovascular events without improving pain relief.
What this interaction means in plain words
Flurbiprofen and Tolfenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flurbiprofen belongs to Musculoskeletal; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Duplicate cyclooxygenase inhibition causes additive suppression of protective prostaglandins and platelet function.
What to do
Avoid concurrent use; use a single NSAID at the lowest effective dose and add paracetamol if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Flurbiprofen with Tolfenamic acid?
MediHelp rates the interaction as major. Flurbiprofen and Tolfenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two NSAIDs together increases the risk of gastrointestinal bleeding, renal injury and cardiovascular events without improving pain relief.
How serious is the interaction between Flurbiprofen and Tolfenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; use a single NSAID at the lowest effective dose and add paracetamol if needed.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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