Drug interactions
Flurbiprofen + Valproic acid
Severity: Minor
Flurbiprofen and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valproic acid may inhibit CYP2C9 and so raise flurbiprofen exposure. Both drugs also impair platelet function, so combined use may increase bleeding tendency.
What this interaction means in plain words
Flurbiprofen and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flurbiprofen belongs to Musculoskeletal; Valproic acid belongs to Central Nervous System.
Why it happens
Valproate may inhibit CYP2C9-mediated flurbiprofen metabolism and has additive effects on platelet function.
What to do
Watch for NSAID adverse effects and signs of bleeding or bruising. Use the lowest effective flurbiprofen dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Frequently asked questions
Can I take Flurbiprofen with Valproic acid?
MediHelp rates the interaction as minor. Flurbiprofen and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valproic acid may inhibit CYP2C9 and so raise flurbiprofen exposure. Both drugs also impair platelet function, so combined use may increase bleeding tendency.
How serious is the interaction between Flurbiprofen and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for NSAID adverse effects and signs of bleeding or bruising. Use the lowest effective flurbiprofen dose.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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