Drug interactions
Flurbiprofen + Vancomycin
Severity: Moderate
Flurbiprofen and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce renal clearance of vancomycin, described mainly in neonates. Higher vancomycin levels raise the risk of nephrotoxicity, and both drugs can harm the kidney.
What this interaction means in plain words
Flurbiprofen and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Vancomycin belongs to Anti Bacterial.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and glomerular filtration, lowering vancomycin clearance.
What to do
Monitor serum creatinine and vancomycin trough levels, and adjust the vancomycin dose as required. Avoid the NSAID where possible in patients with renal risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Flurbiprofen with Vancomycin?
MediHelp rates the interaction as moderate. Flurbiprofen and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce renal clearance of vancomycin, described mainly in neonates. Higher vancomycin levels raise the risk of nephrotoxicity, and both drugs can harm the kidney.
How serious is the interaction between Flurbiprofen and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and vancomycin trough levels, and adjust the vancomycin dose as required. Avoid the NSAID where possible in patients with renal risk.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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