Drug interactions
Flurbiprofen + Voclosporin
Severity: Major
Flurbiprofen and Voclosporin: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can cause dose-related nephrotoxicity, and NSAIDs reduce renal prostaglandin-dependent perfusion. Together they raise the risk of acute kidney injury, which is important in lupus nephritis patients with already compromised kidneys.
What this interaction means in plain words
Flurbiprofen and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flurbiprofen belongs to Musculoskeletal; Voclosporin belongs to Miscellaneous.
Why it happens
Additive renal hemodynamic impairment from afferent arteriolar constriction by voclosporin and prostaglandin inhibition by the NSAID.
What to do
Avoid NSAIDs where possible; if required, use short courses and monitor eGFR, serum creatinine and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Voclosporin?
MediHelp rates the interaction as major. Flurbiprofen and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a calcineurin inhibitor that can cause dose-related nephrotoxicity, and NSAIDs reduce renal prostaglandin-dependent perfusion. Together they raise the risk of acute kidney injury, which is important in lupus nephritis patients with already compromised kidneys.
How serious is the interaction between Flurbiprofen and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible; if required, use short courses and monitor eGFR, serum creatinine and blood pressure.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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