Drug interactions
Flurbiprofen + Warfarin
Severity: Major
Flurbiprofen and Warfarin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen increases bleeding risk in patients on warfarin, especially gastrointestinal bleeding. Flurbiprofen also inhibits platelet function and may cause gastric mucosal injury.
What this interaction means in plain words
Flurbiprofen and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flurbiprofen belongs to Musculoskeletal; Warfarin belongs to Cardiovascular.
Why it happens
Additive effects on hemostasis through platelet inhibition and GI mucosal damage, with possible minor CYP2C9 competition and protein-binding displacement.
What to do
Avoid the combination where possible and use paracetamol as an alternative analgesic. If unavoidable, monitor INR and signs of bleeding and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Flurbiprofen with Warfarin?
MediHelp rates the interaction as major. Flurbiprofen and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Flurbiprofen increases bleeding risk in patients on warfarin, especially gastrointestinal bleeding. Flurbiprofen also inhibits platelet function and may cause gastric mucosal injury.
How serious is the interaction between Flurbiprofen and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use paracetamol as an alternative analgesic. If unavoidable, monitor INR and signs of bleeding and consider gastroprotection.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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