Drug interactions
Flurbiprofen + Zafirlukast
Severity: Minor
Flurbiprofen and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast inhibits CYP2C9 and may modestly raise flurbiprofen exposure. Clinically significant effects are unlikely, but NSAID adverse effects are exposure-related.
What this interaction means in plain words
Flurbiprofen and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flurbiprofen belongs to Musculoskeletal; Zafirlukast belongs to Respiratory.
Why it happens
Zafirlukast inhibits CYP2C9-mediated hydroxylation of flurbiprofen.
What to do
No adjustment needed; use the lowest effective flurbiprofen dose and monitor for GI and renal effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Zafirlukast?
MediHelp rates the interaction as minor. Flurbiprofen and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast inhibits CYP2C9 and may modestly raise flurbiprofen exposure. Clinically significant effects are unlikely, but NSAID adverse effects are exposure-related.
How serious is the interaction between Flurbiprofen and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; use the lowest effective flurbiprofen dose and monitor for GI and renal effects.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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