Drug interactions
Flutamide + Larotrectinib
Severity: Minor
Flutamide and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak inhibitor of CYP3A4, so it might modestly increase flutamide exposure. The clinical effect is probably small.
What this interaction means in plain words
Flutamide and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flutamide belongs to Endocrine; Larotrectinib belongs to Oncology.
Why it happens
Larotrectinib weakly inhibits CYP3A4, slightly reducing flutamide clearance.
What to do
No routine adjustment is needed. Monitor liver function tests as part of normal flutamide therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flutamide
Other interactions of Larotrectinib
Frequently asked questions
Can I take Flutamide with Larotrectinib?
MediHelp rates the interaction as minor. Flutamide and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak inhibitor of CYP3A4, so it might modestly increase flutamide exposure. The clinical effect is probably small.
How serious is the interaction between Flutamide and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor liver function tests as part of normal flutamide therapy.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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