Drug interactions
Fluticasone + Istradefylline
Severity: Minor
Fluticasone and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg/day istradefylline weakly inhibits CYP3A4 and may raise fluticasone exposure. Effects are likely modest at the usual 20 mg dose.
What this interaction means in plain words
Fluticasone and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone belongs to Respiratory; Istradefylline belongs to Central Nervous System.
Why it happens
Dose-dependent weak CYP3A4 inhibition by istradefylline.
What to do
Monitor for corticosteroid systemic effects if the istradefylline dose is 40 mg/day and long-term fluticasone is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone
Other interactions of Istradefylline
Frequently asked questions
Can I take Fluticasone with Istradefylline?
MediHelp rates the interaction as minor. Fluticasone and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg/day istradefylline weakly inhibits CYP3A4 and may raise fluticasone exposure. Effects are likely modest at the usual 20 mg dose.
How serious is the interaction between Fluticasone and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid systemic effects if the istradefylline dose is 40 mg/day and long-term fluticasone is used.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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