Drug interactions
Fluticasone + Larotrectinib
Severity: Minor
Fluticasone and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory activity and is unlikely to change fluticasone exposure meaningfully. Clinical relevance is doubtful.
What this interaction means in plain words
Fluticasone and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone belongs to Respiratory; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib; not well established.
What to do
No specific action is required; monitor for signs of corticosteroid excess during long-term combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone
Other interactions of Larotrectinib
Frequently asked questions
Can I take Fluticasone with Larotrectinib?
MediHelp rates the interaction as minor. Fluticasone and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with weak inhibitory activity and is unlikely to change fluticasone exposure meaningfully. Clinical relevance is doubtful.
How serious is the interaction between Fluticasone and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required; monitor for signs of corticosteroid excess during long-term combined use.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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