Drug interactions
Fluticasone + Rifabutin
Severity: Minor
Fluticasone and Rifabutin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin is a CYP3A4 inducer and may lower systemic fluticasone exposure. The effect on local lung activity is probably small.
What this interaction means in plain words
Fluticasone and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone belongs to Respiratory; Rifabutin belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 metabolism of fluticasone by rifabutin.
What to do
No routine dose change; reassess symptom control and increase fluticasone dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Fluticasone with Rifabutin?
MediHelp rates the interaction as minor. Fluticasone and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifabutin is a CYP3A4 inducer and may lower systemic fluticasone exposure. The effect on local lung activity is probably small.
How serious is the interaction between Fluticasone and Rifabutin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; reassess symptom control and increase fluticasone dose if control worsens.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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