Drug interactions
Fluticasone furoate + Itraconazole
Severity: Major
Fluticasone furoate and Itraconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a potent CYP3A4 inhibitor and can substantially raise systemic exposure to inhaled or intranasal fluticasone. Cushing's syndrome and adrenal suppression have been reported with related fluticasone combinations.
What this interaction means in plain words
Fluticasone furoate and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Potent inhibition of CYP3A4 (and P-gp) by itraconazole decreases the metabolism of fluticasone furoate.
What to do
Avoid prolonged co-administration where possible, or choose an alternative corticosteroid such as beclomethasone. If combined, monitor for Cushing's features and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Fluticasone furoate with Itraconazole?
MediHelp rates the interaction as major. Fluticasone furoate and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole is a potent CYP3A4 inhibitor and can substantially raise systemic exposure to inhaled or intranasal fluticasone. Cushing's syndrome and adrenal suppression have been reported with related fluticasone combinations.
How serious is the interaction between Fluticasone furoate and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged co-administration where possible, or choose an alternative corticosteroid such as beclomethasone. If combined, monitor for Cushing's features and adrenal suppression.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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