Drug interactions
Fluticasone furoate + Letermovir
Severity: Moderate
Fluticasone furoate and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 moderately and may increase fluticasone furoate exposure. Systemic corticosteroid effects are more likely with prolonged use.
What this interaction means in plain words
Fluticasone furoate and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Letermovir inhibits CYP3A4, decreasing fluticasone metabolism.
What to do
Monitor for Cushingoid features and adrenal suppression with extended co-use, and reduce the fluticasone dose if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Fluticasone furoate with Letermovir?
MediHelp rates the interaction as moderate. Fluticasone furoate and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A4 moderately and may increase fluticasone furoate exposure. Systemic corticosteroid effects are more likely with prolonged use.
How serious is the interaction between Fluticasone furoate and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushingoid features and adrenal suppression with extended co-use, and reduce the fluticasone dose if possible.
What other medicines interact with Letermovir?
MediHelp also lists interactions of Letermovir with, for example, Ergotamine, Pimozide, Apalutamide. The full list is on the Letermovir page.
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