Drug interactions
Fluticasone furoate + Ribociclib
Severity: Moderate
Fluticasone furoate and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may moderately increase fluticasone furoate exposure. Systemic corticosteroid effects may become more likely with extended co-use.
What this interaction means in plain words
Fluticasone furoate and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by ribociclib reduces the metabolism of fluticasone furoate.
What to do
Monitor for signs of corticosteroid excess during prolonged co-use and use the lowest effective fluticasone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Fluticasone furoate with Ribociclib?
MediHelp rates the interaction as moderate. Fluticasone furoate and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4 and may moderately increase fluticasone furoate exposure. Systemic corticosteroid effects may become more likely with extended co-use.
How serious is the interaction between Fluticasone furoate and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess during prolonged co-use and use the lowest effective fluticasone dose.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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